UniProt P35240
Merlin (P35240)
Merlin (UniProt P35240): 12 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 19 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35240
- Protein
- Merlin
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 19 · 2 records with a druggable one
Structures
13 records of P35240 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H4R | Crystal Structure of the FERM domain of Merlin, the Neurofibromatosis 2 Tumor Suppressor Protein. | x-ray diffraction | A, B | — | — |
| 1H4R | Crystal structure of the ferm domain of merlin, the neurofibromatosis 2 tumor suppressor protein. | x-ray diffraction | A, B | — | — |
| 3U8Z | human merlin FERM domain | x-ray diffraction | A, B, C, D | — | — |
| 3U8Z | Human merlin ferm domain | x-ray diffraction | A, B, C, D | — | — |
| 4ZRI | Crystal structure of Merlin-FERM and Lats2 | x-ray diffraction | A, B | — | — |
| 4ZRI | Crystal structure of merlin-ferm and LATS2 | x-ray diffraction | A, B | — | — |
| 4ZRJ | Structure of Merlin-FERM and CTD | x-ray diffraction | A, B | — | — |
| 4ZRJ | Structure of merlin-ferm and ctd | x-ray diffraction | A, B | — | — |
| 6CDS | Human neurofibromin 2/merlin/schwannomin residues 1-339 in complex with PIP2 | x-ray diffraction | A, B | PIO, PO4 | 12 (best 0.60) |
| 6CDS | Human neurofibromin 2/MERLIN/SCHWANNOMIN residues 1-339 in complex with PIP2 | x-ray diffraction | A, B | PIO, PO4 | — |
| 7LWH | Human neurofibromin 2/merlin residues 1-339 in complex with LATS1 | x-ray diffraction | A | — | 7 (best 0.64) |
| 7LWH | Human neurofibromin 2/MERLIN residues 1-339 in complex with LATS1 | x-ray diffraction | A | — | — |
| P35240 | AlphaFold monomer V2.0 prediction for merlin (P35240) | predicted | A | — | — |
Ligands
Experiment against prediction
- 4ZRI chain A against the predicted model P35240: TM-score 0.98, RMSD 0.87 Å
- 4ZRI chain A against the predicted model P35240: TM-score 0.98, RMSD 0.87 Å
- 1H4R chain A against the predicted model P35240: TM-score 0.98, RMSD 1.00 Å
- 1H4R chain A against the predicted model P35240: TM-score 0.98, RMSD 1.00 Å
- 4ZRI chain B against the predicted model P35240: TM-score 0.98, RMSD 0.96 Å
- 4ZRI chain B against the predicted model P35240: TM-score 0.98, RMSD 0.96 Å
- 4ZRJ chain A against the predicted model P35240: TM-score 0.97, RMSD 1.32 Å
- 4ZRJ chain A against the predicted model P35240: TM-score 0.97, RMSD 1.32 Å
- 3U8Z chain D against the predicted model P35240: TM-score 0.96, RMSD 1.19 Å
- 3U8Z chain D against the predicted model P35240: TM-score 0.96, RMSD 1.19 Å
Elsewhere
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