Research workbench

Structure of the mRNA splicing complex component CWC2

Analyse Structure of the mRNA splicing complex component CWC2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3U1L
Type: protein
Length: 216 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-splicing factor CWC2
UniProt: Q12046
Ligands: ZN
Pockets: 4 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-splicing factor CWC2	protein	216	37% helix, 14% strand	Q12046

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	123	0.53	0.82	24	empty
2	216	0.51	0.76	37	empty
3	86	0.45	0.80	16	empty
4	60	0.39	0.79	13	empty

Compared structures

3U1L · Structure of the mRNA splicing complex component Cwc2 · the same entry in another collection · chain A against A, TM-score 1.00
Q12046 · AlphaFold monomer V2.0 prediction for pre-mRNA-splicing factor CWC2 (Q12046) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12046
Elsewhere: RCSB PDB 3U1L · PDBe 3U1L · UniProt Q12046

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.