Research workbench
Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from human lnpep (chimeric peptide)
Analyse Crystal structure of ARC4 from human tankyrase 2 in complex with peptide from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TWW
- Type
- protein
- Length
- 337 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tankyrase-2; Human lnpep
- EC
- 2.4.2.30
- UniProt
- Q9H2K2
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 46% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tankyrase-2 (EC 2.4.2.30) | protein | 157 | 50% helix, 0% strand | Q9H2K2 |
| B | Tankyrase-2 (EC 2.4.2.30) | protein | 157 | 49% helix, 0% strand | Q9H2K2 |
| C | Human lnpep | protein | 12 | 0% helix, 0% strand | — |
| D | Human lnpep | protein | 11 | 0% helix, 0% strand | — |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.74 | 0.85 | 43 | empty |
| 2 | 140 | 0.43 | 0.76 | 17 | SO4 |
Interfaces
6 interfaces between chains.
- A–C · 712 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 678 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 293 Ų buried · 8 hydrogen bonds · protein-protein
- A–D · 262 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 239 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
- 3TWW · Crystal structure of ARC4 from human Tankyrase 2 in complex with peptide from human LNPEP… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H2K2
- Elsewhere: RCSB PDB 3TWW · PDBe 3TWW · UniProt Q9H2K2
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