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Crystal structure of human septin 7 GTPase domain

Analyse Crystal structure of human septin 7 GTPase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3TW4
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Septin-7
UniProt: Q16181
Ligands: GDP
Pockets: 4 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Septin-7	protein	218	41% helix, 12% strand	Q16181
B	Septin-7	protein	212	40% helix, 15% strand	Q16181

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	963	0.85	0.86	109	GDP
2	456	0.77	0.85	43	empty
3	546	0.75	0.82	61	empty
4	93	0.35	0.74	24	GDP

Interfaces

1 interface between chains.

A–B · 599 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

3TW4 · Crystal Structure of Human Septin 7 GTPase Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q16181 · AlphaFold monomer V2.0 prediction for septin-7 (Q16181) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16181
Elsewhere: RCSB PDB 3TW4 · PDBe 3TW4 · UniProt Q16181

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