Research workbench
Crystal structure of the SIR3 bah domain in complex with a nucleosome core particle.
Analyse Crystal structure of the SIR3 bah domain in complex with a nucleosome core… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TU4
- Type
- protein + DNA
- Length
- 1,491 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H3.2; Histone H4; Histone H2A; Histone H2B 1.1; Regulatory protein SIR3; DNA…
- UniProt
- P84233, P62799, Q6AZJ8, P02281, P06701
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 10 distinct chains · 46% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H3.2 | protein | 98 | 64% helix, 4% strand | P84233 |
| B | Histone H4 | protein | 89 | 55% helix, 7% strand | P62799 |
| C, G | Histone H2A | protein | 107 | 53% helix, 6% strand | Q6AZJ8 |
| D, H | Histone H2B 1.1 | protein | 93 | 74% helix, 4% strand | P02281 |
| E | Histone H3.2 | protein | 95 | 65% helix, 4% strand | P84233 |
| F | Histone H4 | protein | 90 | 56% helix, 7% strand | P62799 |
| K | Regulatory protein SIR3 | protein | 214 | 24% helix, 32% strand | P06701 |
| L | Regulatory protein SIR3 | protein | 213 | 26% helix, 31% strand | P06701 |
| I | DNA (146-mer) | dna | 146 | — | — |
| J | DNA (146-mer) | dna | 146 | — | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 772 | 0.81 | 0.85 | 85 | empty |
| 2 | 775 | 0.79 | 0.83 | 77 | empty |
| 3 | 546 | 0.76 | 0.83 | 54 | empty |
| 4 | 391 | 0.75 | 0.85 | 54 | empty |
| 5 | 454 | 0.75 | 0.84 | 49 | empty |
Interfaces
47 interfaces between chains.
- I–J · 6599 Ų buried · 669 hydrogen bonds · nucleic-nucleic
- A–B · 2650 Ų buried · 26 hydrogen bonds · protein-protein
- E–F · 2640 Ų buried · 23 hydrogen bonds · protein-protein
- C–D · 2596 Ų buried · 25 hydrogen bonds · protein-protein
- G–H · 2571 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 3TU4 · Crystal structure of the Sir3 BAH domain in complex with a nucleosome core particle. · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84233
- Every structure of UniProt P62799
- Every structure of UniProt Q6AZJ8
- Every structure of UniProt P02281
- Every structure of UniProt P06701
- Elsewhere: RCSB PDB 3TU4 · PDBe 3TU4 · UniProt P84233 · UniProt P62799 · UniProt Q6AZJ8 · UniProt P02281 · UniProt P06701
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.