Research workbench
Crystal structure of PDZ3-SH3-guk core module from human zo-1 in complex with 12MER peptide from human jam-a cytoplasmic tail
Analyse Crystal structure of PDZ3-SH3-guk core module from human zo-1 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TSZ
- Type
- protein
- Length
- 351 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tight junction protein zo-1; Junctional adhesion molecule a
- UniProt
- Q07157, Q9Y624
- Pockets
- 3 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tight junction protein zo-1 | protein | 341 | 31% helix, 29% strand | Q07157 |
| B | Junctional adhesion molecule a | protein | 10 | 0% helix, 0% strand | Q9Y624 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 396 | 0.66 | 0.80 | 36 | empty |
| 2 | 186 | 0.51 | 0.77 | 25 | empty |
| 3 | 55 | 0.25 | 0.73 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 808 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 3TSZ · crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07157 · AlphaFold monomer V2.0 prediction for tight junction protein zo-1 (Q07157) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9Y624 · AlphaFold monomer V2.0 prediction for junctional adhesion molecule a (Q9Y624) · a predicted model of the same protein · chain B against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07157
- Every structure of UniProt Q9Y624
- Elsewhere: RCSB PDB 3TSZ · PDBe 3TSZ · UniProt Q07157 · UniProt Q9Y624
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.