Research workbench
Crystal structure of a light chain domain of scallop smooth muscle myosin
Analyse Crystal structure of a light chain domain of scallop smooth muscle myosin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TS5
- Type
- protein
- Length
- 728 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin heavy chain; Myosin regulatory light chain; Myosin essential light chain
- UniProt
- Q26080, Q26069, Q26066
- Ligands
- MG, CA
- Pockets
- 5 · best druggability 0.63
Structure
x-ray diffraction · 6 distinct chains · 63% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin heavy chain | protein | 68 | 93% helix, 0% strand | Q26080 |
| B | Myosin regulatory light chain | protein | 142 | 58% helix, 6% strand | Q26069 |
| C | Myosin essential light chain | protein | 152 | 56% helix, 8% strand | Q26066 |
| D | Myosin heavy chain | protein | 69 | 93% helix, 0% strand | Q26080 |
| E | Myosin regulatory light chain | protein | 146 | 55% helix, 4% strand | Q26069 |
| F | Myosin essential light chain | protein | 151 | 56% helix, 7% strand | Q26066 |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains B, E
- CA · Calcium ion · metal · 2 copies · chains C, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 553 | 0.63 | 0.75 | 54 | empty |
| 2 | 74 | 0.52 | 0.85 | 21 | empty |
| 3 | 140 | 0.44 | 0.75 | 19 | empty |
| 4 | 97 | 0.39 | 0.75 | 17 | empty |
| 5 | 81 | 0.37 | 0.76 | 17 | empty |
Interfaces
7 interfaces between chains.
- A–B · 2062 Ų buried · 23 hydrogen bonds · protein-protein
- D–E · 2008 Ų buried · 24 hydrogen bonds · protein-protein
- A–C · 1931 Ų buried · 24 hydrogen bonds · protein-protein
- D–F · 1911 Ų buried · 19 hydrogen bonds · protein-protein
- B–F · 305 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 3TS5 · Crystal Structure of a Light Chain Domain of Scallop Smooth Muscle Myosin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q26080
- Every structure of UniProt Q26069
- Every structure of UniProt Q26066
- Elsewhere: RCSB PDB 3TS5 · PDBe 3TS5 · UniProt Q26080 · UniProt Q26069 · UniProt Q26066
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