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Crystal structure of native rabbit skeletal calsequestrin
Analyse Crystal structure of native rabbit skeletal calsequestrin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TRQ
- Type
- protein
- Length
- 353 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calsequestrin-1
- UniProt
- P07221
- Ligands
- NAG, BMA, MAN, CA, NA
- Pockets
- 10 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calsequestrin-1 | protein | 353 | 39% helix, 19% strand | P07221 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- BMA · beta-D-mannopyranose · sugar
- MAN · alpha-D-mannopyranose · sugar
- CA · Calcium ion · metal · 6 copies · chains A
- NA · Sodium ion · metal · 3 copies · chains A
- MRD · (4R)-2-methylpentane-2,4-diol · additive · 2 copies · chains A
- MPD · (4S)-2-methyl-2,4-pentanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 148 | 0.70 | 0.90 | 18 | empty |
| 2 | 105 | 0.48 | 0.79 | 16 | MPD |
| 3 | 113 | 0.41 | 0.76 | 19 | MRD |
| 4 | 91 | 0.38 | 0.76 | 20 | empty |
| 5 | 68 | 0.33 | 0.76 | 15 | empty |
Modifications
Observed in the structure: 1 glycan (N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07221
- Elsewhere: RCSB PDB 3TRQ · PDBe 3TRQ · UniProt P07221
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