Research workbench
Crystal structure of dual-specific a-kinase anchoring protein 2 in complex with camp-dependent protein kinase a type II alpha and PDZK1
Analyse Crystal structure of dual-specific a-kinase anchoring protein 2 in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TMH
- Type
- protein
- Length
- 471 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NA(+)/H(+) exchange regulatory cofactor nhe-RF3; Camp-dependent protein kinase type…
- UniProt
- Q5T2W1, P12368, O43572
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 8 distinct chains · 51% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, I | NA(+)/H(+) exchange regulatory cofactor nhe-RF3 | protein | 82 | 17% helix, 37% strand | Q5T2W1 |
| B | Camp-dependent protein kinase type II-alpha regulatory subunit | protein | 36 | 75% helix, 0% strand | P12368 |
| C | Camp-dependent protein kinase type II-alpha regulatory subunit | protein | 39 | 64% helix, 0% strand | P12368 |
| D | A-kinase anchor protein 10, mitochondrial | protein | 28 | 54% helix, 18% strand | O43572 |
| F | Camp-dependent protein kinase type II-alpha regulatory subunit | protein | 39 | 69% helix, 0% strand | P12368 |
| G | Camp-dependent protein kinase type II-alpha regulatory subunit | protein | 33 | 70% helix, 0% strand | P12368 |
| H | A-kinase anchor protein 10, mitochondrial | protein | 23 | 48% helix, 22% strand | O43572 |
| L | A-kinase anchor protein 10, mitochondrial | protein | 27 | 56% helix, 19% strand | O43572 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 229 | 0.50 | 0.75 | 34 | empty |
Interfaces
14 interfaces between chains.
- B–C · 869 Ų buried · 8 hydrogen bonds · protein-protein
- F–G · 660 Ų buried · 3 hydrogen bonds · protein-protein
- I–L · 559 Ų buried · 24 hydrogen bonds · protein-protein
- E–H · 558 Ų buried · 20 hydrogen bonds · protein-protein
- A–D · 556 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 3TMH · Crystal structure of dual-specific A-kinase anchoring protein 2 in complex with… · the same entry in another collection · chain L against L, TM-score 1.00
- Q5T2W1 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF3… · a predicted model of the same protein · chain A against A, TM-score 0.96
- P12368 · AlphaFold monomer V2.0 prediction for camp-dependent protein kinase type II-alpha… · a predicted model of the same protein · chain B against A, TM-score 0.90
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5T2W1
- Every structure of UniProt P12368
- Every structure of UniProt O43572
- Elsewhere: RCSB PDB 3TMH · PDBe 3TMH · UniProt Q5T2W1 · UniProt P12368 · UniProt O43572
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