Research workbench
Structure of importin A5 bound to the N-terminus of NUP50
Analyse Structure of importin A5 bound to the N-terminus of NUP50 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TJ3
- Type
- protein
- Length
- 953 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Nuclear pore complex protein NUP50
- UniProt
- P52294, Q9UKX7
- Pockets
- 7 · best druggability 0.84
Structure
x-ray diffraction · 3 distinct chains · 60% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Importin subunit alpha-1 | protein | 426 | 71% helix, 0% strand | P52294 |
| C | Nuclear pore complex protein NUP50 | protein | 51 | 12% helix, 2% strand | Q9UKX7 |
| D | Nuclear pore complex protein NUP50 | protein | 50 | 12% helix, 4% strand | Q9UKX7 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1172 | 0.84 | 0.85 | 94 | empty |
| 2 | 254 | 0.65 | 0.82 | 32 | empty |
| 3 | 240 | 0.61 | 0.81 | 30 | empty |
| 4 | 52 | 0.55 | 0.89 | 20 | empty |
| 5 | 202 | 0.51 | 0.77 | 39 | empty |
Interfaces
5 interfaces between chains.
- B–D · 2326 Ų buried · 37 hydrogen bonds · protein-protein
- A–C · 2290 Ų buried · 36 hydrogen bonds · protein-protein
- A–B · 600 Ų buried · 9 hydrogen bonds · protein-protein
- C–B · 229 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 214 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3TJ3 · Structure of importin a5 bound to the N-terminus of Nup50 · the same entry in another collection · chain A against A, TM-score 1.00
- P52294 · AlphaFold monomer V2.0 prediction for importin subunit alpha-5 (P52294) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q9UKX7 · AlphaFold monomer V2.0 prediction for nuclear pore complex protein NUP50 (Q9UKX7) · a predicted model of the same protein · chain C against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52294
- Every structure of UniProt Q9UKX7
- Elsewhere: RCSB PDB 3TJ3 · PDBe 3TJ3 · UniProt P52294 · UniProt Q9UKX7
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