Research workbench
Crystal structure analysis of W35F/H207W mutant of human CLIC1
Analyse Crystal structure analysis of W35F/H207W mutant of human CLIC1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TGZ
- Type
- protein
- Length
- 472 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chloride intracellular channel protein 1
- UniProt
- O00299
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Chloride intracellular channel protein 1 | protein | 236 | 50% helix, 9% strand | O00299 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 202 | 0.50 | 0.76 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 507 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3TGZ · Crystal Structure Analysis of W35F/H207W Mutant of Human CLIC1 · the same entry in another collection · chain A against A, TM-score 1.00
- O00299 · AlphaFold monomer V2.0 prediction for chloride intracellular channel protein 1 (O00299) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00299
- Elsewhere: RCSB PDB 3TGZ · PDBe 3TGZ · UniProt O00299
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