Research workbench
Crystal structure of the cap free human translation initiation factor EIF4E
Analyse Crystal structure of the cap free human translation initiation factor EIF4E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3TF2
- Type
- protein
- Length
- 696 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Eukaryotic translation initiation factor 4E
- UniProt
- P06730
- Ligands
- UNX
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 31% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Eukaryotic translation initiation factor 4E | protein | 177 | 31% helix, 29% strand | P06730 |
| B | Eukaryotic translation initiation factor 4E | protein | 176 | 33% helix, 30% strand | P06730 |
| C | Eukaryotic translation initiation factor 4E | protein | 175 | 32% helix, 29% strand | P06730 |
| D | Eukaryotic translation initiation factor 4E | protein | 168 | 30% helix, 30% strand | P06730 |
Ligands and binding sites
- UNX · Unknown atom or ion · ion · 14 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1097 | 0.75 | 0.78 | 86 | UNX |
| 2 | 371 | 0.65 | 0.79 | 34 | UNX |
| 3 | 106 | 0.58 | 0.86 | 18 | empty |
| 4 | 113 | 0.49 | 0.80 | 19 | empty |
| 5 | 174 | 0.47 | 0.75 | 18 | UNX |
Interfaces
3 interfaces between chains.
- B–C · 757 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 743 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 378 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3TF2 · Crystal structure of the cap free human translation initiation factor eIF4E · the same entry in another collection · chain D against D, TM-score 1.00
- P06730 · AlphaFold monomer V2.0 prediction for eukaryotic translation initiation factor 4E (P06730) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06730
- Elsewhere: RCSB PDB 3TF2 · PDBe 3TF2 · UniProt P06730
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