Research workbench
Complex structure of RTT107P and phosphorylated histone H2A
Analyse Complex structure of RTT107P and phosphorylated histone H2A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3T7K
- Type
- protein
- Length
- 477 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Regulator of TY1 transposition protein 107; Histone H2A.1
- UniProt
- P38850, P04911
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Regulator of TY1 transposition protein 107 | protein | 233 | 34% helix, 17% strand | P38850 |
| C, D | Histone H2A.1 | protein | 5 | 0% helix, 20% strand | P04911 |
| B | Regulator of TY1 transposition protein 107 | protein | 234 | 34% helix, 17% strand | P38850 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 495 | 0.64 | 0.77 | 43 | empty |
| 2 | 66 | 0.45 | 0.83 | 13 | empty |
| 3 | 58 | 0.42 | 0.82 | 13 | empty |
| 4 | 67 | 0.38 | 0.79 | 19 | empty |
| 5 | 54 | 0.27 | 0.74 | 12 | empty |
Interfaces
3 interfaces between chains.
- A–B · 465 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 389 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 373 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 3T7K · Complex structure of Rtt107p and phosphorylated histone H2A · the same entry in another collection · chain A against A, TM-score 1.00
- P38850 · AlphaFold monomer V2.0 prediction for regulator of TY1 transposition protein 107 (P38850) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P04911 · AlphaFold monomer V2.0 prediction for histone H2A.1 (P04911) · a predicted model of the same protein · chain C against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38850
- Every structure of UniProt P04911
- Elsewhere: RCSB PDB 3T7K · PDBe 3T7K · UniProt P38850 · UniProt P04911
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