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1.8A crystal structure of lassa virus nucleoprotein in complex with ssrna

Analyse 1.8A crystal structure of lassa virus nucleoprotein in complex with ssrna in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3T5N
Type: protein + RNA
Length: 288 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoprotein; RNA (5'-R(P*UP*AP*UP*CP*UP*C)-3')
UniProt: Q5S585
Ligands: NI
Pockets: 2 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 55% helix, 5% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoprotein	protein	282	55% helix, 5% strand	Q5S585
C	RNA (5'-R(PUPAPUPCPUPC)-3')	rna	6	—	—

Ligands and binding sites

NI · Nickel (II) ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	326	0.81	0.91	32	empty
2	71	0.37	0.79	15	empty

Interfaces

1 interface between chains.

A–C · 961 Å² buried · 33 hydrogen bonds · protein-nucleic

Compared structures

3T5N · 1.8A crystal structure of Lassa virus nucleoprotein in complex with ssRNA · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5S585
Elsewhere: RCSB PDB 3T5N · PDBe 3T5N · UniProt Q5S585

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