Research workbench
Structure of a truncated form of staphylococcal complement inhibitor B bound to human C3C at 3.4 ångström resolution
Analyse Structure of a truncated form of staphylococcal complement inhibitor B bound to… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3T4A
- Type
- protein
- Length
- 2,360 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement C3 beta chain; Complement C3C alpha' chain fragment 1; Complement C3C alpha'…
- UniProt
- P01024, Q99UU9
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Complement C3 beta chain | protein | 633 | 7% helix, 48% strand | P01024 |
| B, E | Complement C3C alpha' chain fragment 1 | protein | 183 | 2% helix, 53% strand | P01024 |
| C, F | Complement C3C alpha' chain fragment 2 | protein | 296 | 14% helix, 35% strand | P01024 |
| G, H | Fibrinogen-binding protein | protein | 68 | 84% helix, 0% strand | Q99UU9 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 497 | 0.74 | 0.83 | 45 | empty |
| 2 | 876 | 0.74 | 0.78 | 66 | empty |
| 3 | 461 | 0.74 | 0.83 | 45 | empty |
| 4 | 754 | 0.72 | 0.78 | 55 | empty |
| 5 | 72 | 0.72 | 0.96 | 25 | empty |
Interfaces
13 interfaces between chains.
- D–E · 3516 Ų buried · 60 hydrogen bonds · protein-protein
- A–B · 3499 Ų buried · 53 hydrogen bonds · protein-protein
- B–C · 1219 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 1123 Ų buried · 11 hydrogen bonds · protein-protein
- D–F · 721 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide (disulfide).
Compared structures
- 3T4A · Structure of a truncated form of Staphylococcal Complement Inhibitor B bound to human C3c… · the same entry in another collection · chain H against H, TM-score 1.00
- P01024 · AlphaFold monomer V2.0 prediction for complement C3 (P01024) · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01024
- Every structure of UniProt Q99UU9
- Elsewhere: RCSB PDB 3T4A · PDBe 3T4A · UniProt P01024 · UniProt Q99UU9
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