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Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (KIR3.2) D228N mutant
Analyse Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SYC
- Type
- protein
- Length
- 310 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G protein-activated inward rectifier potassium channel 2
- UniProt
- P48542
- Ligands
- K
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G protein-activated inward rectifier potassium channel 2 | protein | 310 | 34% helix, 27% strand | P48542 |
Ligands and binding sites
- K · Potassium ion · metal · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.32 | 0.75 | 15 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3SYC · Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) D228N… · the same entry in another collection · chain A against A, TM-score 1.00
- P48542 · AlphaFold monomer V2.0 prediction for G protein-activated inward rectifier potassium… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48542
- Elsewhere: RCSB PDB 3SYC · PDBe 3SYC · UniProt P48542
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