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Structure of the C-terminal region (modules 18-20) of complement regulator factor H

Analyse Structure of the C-terminal region (modules 18-20) of complement regulator… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SW0
Type: protein
Length: 186 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Complement factor H
UniProt: P08603
Ligands: PO4
Pockets: 1 · best druggability 0.40

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Complement factor H	protein	186	4% helix, 38% strand	P08603

Ligands and binding sites

PO4 · Phosphate ion · ion · chains X
GOL · Glycerol · additive · 4 copies · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	132	0.40	0.74	22	empty

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3SW0 · Structure of the C-terminal region (modules 18-20) of complement regulator Factor H · the same entry in another collection · chain X against X, TM-score 1.00
P08603 · AlphaFold monomer V2.0 prediction for complement factor H (P08603) · a predicted model of the same protein · chain X against A, TM-score 0.65

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08603
Elsewhere: RCSB PDB 3SW0 · PDBe 3SW0 · UniProt P08603

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