Research workbench

Human MPP8 - human DNMT3AK47ME2 peptide

Analyse Human MPP8 - human DNMT3AK47ME2 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SVM
Type: protein
Length: 72 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: M-phase phosphoprotein 8; DNA (cytosine-5)-methyltransferase 3A
EC: 2.1.1.37
UniProt: Q99549, Q9Y6K1

Structure

x-ray diffraction · 2 distinct chains · 25% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	M-phase phosphoprotein 8	protein	60	30% helix, 40% strand	Q99549
P	DNA (cytosine-5)-methyltransferase 3A (EC 2.1.1.37)	protein	12	0% helix, 17% strand	Q9Y6K1

Interfaces

1 interface between chains.

A–P · 688 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

3SVM · Human MPP8 - human DNMT3AK47me2 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Q99549 · AlphaFold monomer V2.0 prediction for M-phase phosphoprotein 8 (Q99549) · a predicted model of the same protein · chain A against A, TM-score 0.87
Q9Y6K1 · AlphaFold monomer V2.0 prediction for DNA (cytosine-5)-methyltransferase 3A (Q9Y6K1) · a predicted model of the same protein · chain P against A, TM-score 0.37

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99549
Every structure of UniProt Q9Y6K1
Elsewhere: RCSB PDB 3SVM · PDBe 3SVM · UniProt Q99549 · UniProt Q9Y6K1

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