UniProt Q9Y6K1
DNA (cytosine-5)-methyltransferase 3A (Q9Y6K1)
DNA (cytosine-5)-methyltransferase 3A (UniProt Q9Y6K1), EC 2.1.1.-, 2.1.1.37: 44 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 187 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9Y6K1
- Protein
- DNA (cytosine-5)-methyltransferase 3A
- EC
- 2.1.1.-, 2.1.1.37
- Experimental structures
- 44
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 187 · 15 records with a druggable one
Structures
45 records of Q9Y6K1 in the MolNFT archive: 44 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QRV | Structure of Dnmt3a-Dnmt3L C-terminal domain complex | x-ray diffraction | A, D, E, H | — | — |
| 2QRV | Structure of DNMT3A-DNMT3L C-terminal domain complex | x-ray diffraction | A, D, E, H | — | — |
| 3A1A | Crystal Structure of the DNMT3A ADD domain | x-ray diffraction | A | — | — |
| 3A1A | Crystal structure of the DNMT3A add domain | x-ray diffraction | A | — | — |
| 3A1B | Crystal structure of the DNMT3A ADD domain in complex with histone H3 | x-ray diffraction | A | — | — |
| 3A1B | Crystal structure of the DNMT3A add domain in complex with histone H3 | x-ray diffraction | A | — | — |
| 3LLR | Crystal structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 alpha | x-ray diffraction | A, B, C, D, E | — | — |
| 3LLR | Crystal structure of the pwwp domain of human DNA (cytosine-5-)- methyltransferase 3 alpha | x-ray diffraction | A, B, C, D, E | — | — |
| 3SVM | Human MPP8 - human DNMT3AK47me2 peptide | x-ray diffraction | P | — | — |
| 3SVM | Human MPP8 - human DNMT3AK47ME2 peptide | x-ray diffraction | P | — | — |
| 4QBQ | Crystal structure of DNMT3a ADD domain bound to H3 peptide | x-ray diffraction | A, C | — | — |
| 4QBQ | Crystal structure of DNMT3A add domain bound to H3 peptide | x-ray diffraction | A, C | — | — |
| 4QBR | Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide | x-ray diffraction | A, C | — | — |
| 4QBR | Crystal structure of DNMT3A add domain G550D mutant bound to H3 peptide | x-ray diffraction | A, C | — | — |
| 4QBS | Crystal structure of DNMT3a ADD domain E545R mutant bound to H3T3ph peptide | x-ray diffraction | A | — | — |
| 4QBS | Crystal structure of DNMT3A add domain E545R mutant bound to H3T3PH peptide | x-ray diffraction | A | — | — |
| 4U7P | Crystal structure of DNMT3A-DNMT3L complex | x-ray diffraction | A | — | — |
| 4U7P | Crystal structure of DNMT3A-DNMT3L complex | x-ray diffraction | A | — | — |
| 4U7T | Crystal structure of DNMT3A-DNMT3L in complex with histone H3 | x-ray diffraction | A, C | — | — |
| 4U7T | Crystal structure of DNMT3A-DNMT3L in complex with histone H3 | x-ray diffraction | A, C | — | — |
| 5YX2 | Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two CpG sites | x-ray diffraction | A, D | SAH | 13 (best 0.67) |
| 5YX2 | Crystal structure of DNMT3A-DNMT3L in complex with DNA containing two cpg sites | x-ray diffraction | A, D | — | — |
| 6BRR | Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two CpG sites | x-ray diffraction | A, D | SAH | 11 (best 0.67) |
| 6BRR | Crystal structure of DNMT3A (R836A)-DNMT3L in complex with DNA containing two cpg sites | x-ray diffraction | A, D | — | — |
| 6F57 | Crystal structure of DNMT3A-DNMT3L in complex with single CpG-containing DNA | x-ray diffraction | A, D | SAH | 11 (best 0.69) |
| 6F57 | Crystal structure of DNMT3A-DNMT3L in complex with single cpg- containing DNA | x-ray diffraction | A, D | — | — |
| 6PA7 | The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. | electron microscopy | K, P | SAH | 4 (best 0.75) |
| 6PA7 | The cryo-EM structure of the human DNMT3A2-DNMT3B3 complex bound to nucleosome. | electron microscopy | K, P | — | — |
| 6W89 | Structure of DNMT3A (R882H) in complex with CGA DNA | x-ray diffraction | A, D, G, J | SAH | 18 (best 0.74) |
| 6W89 | Structure of DNMT3A (R882H) in complex with cga DNA | x-ray diffraction | A, D, G, J | — | — |
| 6W8B | Structure of DNMT3A in complex with CGA DNA | x-ray diffraction | A, D, H, K | SAH | 18 (best 0.74) |
| 6W8B | Structure of DNMT3A in complex with cga DNA | x-ray diffraction | A, D, H, K | — | — |
| 6W8D | Structure of DNMT3A (R882H) in complex with CGT DNA | x-ray diffraction | A, D | SAH | 13 (best 0.73) |
| 6W8D | Structure of DNMT3A (R882H) in complex with cgt DNA | x-ray diffraction | A, D | — | — |
| 6W8J | Structure of DNMT3A (R882H) in complex with CAG DNA | x-ray diffraction | A, D | SAH | 12 (best 0.77) |
| 6W8J | Structure of DNMT3A (R882H) in complex with cag DNA | x-ray diffraction | A, D | — | — |
| 8BA5 | Crystal structure of the DNMT3A ADD domain | x-ray diffraction | A | ZN, MG | — |
| 8QZM | Structure of DNMT3A1 UDR region bound to H2AK119ub nucleosome | electron microscopy | K | — | 2 (best 0.81) |
| 8TDR | Crystal structure of the methyltransferase domain of DNMT3A homotetramer | x-ray diffraction | A, B, C, E, H, F, D, G | SAH | 20 (best 0.85) |
| 8TE1 | Crystal structure of the methyltransferase domain of R882H/R676K DNMT3A homotetramer | x-ray diffraction | A, B, C, E, H, F, D, G | SAH | 20 (best 0.84) |
| 8TE3 | Crystal structure of the methyltransferase domain of R882C/R676K DNMT3A homotetramer | x-ray diffraction | A, B, C, E, H, F, D, G | SAH | 20 (best 0.85) |
| 8TE4 | Crystal structure of the methyltransferase domain of R882H/N879A DNMT3A homotetramer | x-ray diffraction | A, B, C, E, H, F, D, G | SAH | 20 (best 0.85) |
| 8U5H | Cryo-EM structure of human DNMT3A UDR bound to H2AK119ub1-modified nucleosome | electron microscopy | A, B | — | 3 (best 0.82) |
| 8UW1 | Cryo-EM structure of DNMT3A1 UDR in complex with H2AK119Ub-nucleosome | electron microscopy | K | — | 2 (best 0.81) |
| Q9Y6K1 | AlphaFold monomer V2.0 prediction for DNA (cytosine-5)-methyltransferase 3A (Q9Y6K1) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6F57 chain D against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.59 Å
- 6W89 chain G against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.60 Å
- 4U7T chain A against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.66 Å
- 4U7T chain A against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.66 Å
- 4U7T chain C against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.67 Å
- 4U7T chain C against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.67 Å
- 6W89 chain A against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.67 Å
- 2QRV chain H against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.52 Å
- 2QRV chain H against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.52 Å
- 6W8J chain A against the predicted model Q9Y6K1: TM-score 0.99, RMSD 0.67 Å
Elsewhere
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