Research workbench
Human M2 pyruvate kinase
Analyse Human M2 pyruvate kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SRH
- Type
- protein
- Length
- 2,072 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pyruvate kinase isozymes M1/M2
- EC
- 2.7.1.40
- UniProt
- P14618
- Ligands
- PO4
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Pyruvate kinase isozymes M1/M2 (EC 2.7.1.40) | protein | 518 | 38% helix, 20% strand | P14618 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 3 copies · chains A, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 825 | 0.86 | 0.89 | 55 | empty |
| 2 | 286 | 0.86 | 0.96 | 41 | empty |
| 3 | 327 | 0.86 | 0.95 | 43 | empty |
| 4 | 276 | 0.74 | 0.87 | 32 | empty |
| 5 | 590 | 0.72 | 0.80 | 77 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2819 Ų buried · 39 hydrogen bonds · protein-protein
- A–D · 2815 Ų buried · 33 hydrogen bonds · protein-protein
- C–D · 1475 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1418 Ų buried · 23 hydrogen bonds · protein-protein
- B–D · 46 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3SRH · Human M2 pyruvate kinase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14618
- Elsewhere: RCSB PDB 3SRH · PDBe 3SRH · UniProt P14618
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.