Research workbench
Serum paraoxonase-1 by directed evolution at pH 6.5
Analyse Serum paraoxonase-1 by directed evolution at pH 6.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SRE
- Type
- protein
- Length
- 329 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serum paraoxonase
- EC
- 3.1.1.2
- Ligands
- CA, PO4, BR
- Pockets
- 2 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 9% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum paraoxonase (EC 3.1.1.2) | protein | 329 | 9% helix, 48% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A
- PO4 · Phosphate ion · ion · chains A
- BR · Bromide ion · ion · chains A
- LMT · Dodecyl-beta-D-maltoside · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 350 | 0.65 | 0.80 | 35 | PO4 |
| 2 | 262 | 0.63 | 0.81 | 36 | CA |
Compared structures
- 3SRE · Serum paraoxonase-1 by directed evolution at pH 6.5 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3SRE · PDBe 3SRE
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