Research workbench
Binary complex between IFNA2 and IFNAR2
Analyse Binary complex between IFNA2 and IFNAR2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S9D
- Type
- protein
- Length
- 609 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interferon alpha-2; Interferon ALPHA/BETA receptor 2
- UniProt
- P01563, P48551
- Ligands
- CL
- Pockets
- 4 · best druggability 0.48
Structure
x-ray diffraction · 4 distinct chains · 33% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interferon alpha-2 | protein | 127 | 77% helix, 0% strand | P01563 |
| B | Interferon ALPHA/BETA receptor 2 | protein | 180 | 4% helix, 50% strand | P48551 |
| C | Interferon alpha-2 | protein | 116 | 77% helix, 0% strand | P01563 |
| D | Interferon ALPHA/BETA receptor 2 | protein | 186 | 4% helix, 51% strand | P48551 |
Ligands and binding sites
- CL · Chloride ion · ion · chains C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 179 | 0.48 | 0.76 | 28 | empty |
| 2 | 104 | 0.44 | 0.79 | 18 | empty |
| 3 | 127 | 0.41 | 0.75 | 16 | empty |
| 4 | 67 | 0.37 | 0.78 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 968 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 919 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 515 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3S9D · binary complex between IFNa2 and IFNAR2 · the same entry in another collection · chain D against D, TM-score 1.00
- P01563 · AlphaFold monomer V2.0 prediction for interferon alpha-2 (P01563) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P48551 · AlphaFold monomer V2.0 prediction for interferon ALPHA/BETA receptor 2 (P48551) · a predicted model of the same protein · chain D against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01563
- Every structure of UniProt P48551
- Elsewhere: RCSB PDB 3S9D · PDBe 3S9D · UniProt P01563 · UniProt P48551
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