UniProt P01563
Interferon alpha-2 (P01563)
Interferon alpha-2 (UniProt P01563): 18 experimental structures and 1 predicted model on GenesisL1, 2 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01563
- Protein
- Interferon alpha-2
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 2 · 1 record with a druggable one
Structures
19 records of P01563 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ITF | Interferon alpha-2A, NMR, 24 structures | solution nmr | A | — | — |
| 1ITF | Interferon alpha-2A, NMR, 24 structures | solution nmr | A | — | — |
| 1RH2 | Recombinant human interferon-alpha 2B | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1RH2 | Recombinant human interferon-alpha 2B | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2HYM | NMR based Docking Model of the Complex between the Human Type I Interferon Receptor and Human… | solution nmr | B | — | — |
| 2HYM | NMR based docking model of the complex between the human type I interferon receptor and human… | solution nmr | B | — | — |
| 2KZ1 | Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric… | solution nmr | A | — | — |
| 2KZ1 | Inter-molecular interactions in a 44 kda interferon-receptor complex detected by asymmetric… | solution nmr | A | — | — |
| 2LAG | Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of IFNAR2 obtained… | solution nmr | A | — | — |
| 2LAG | Structure of the 44 kda complex of interferon-ALPHA2 with the extracellular part of IFNAR2 obtained… | solution nmr | A | — | — |
| 2LMS | A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon… | solution nmr | A | — | — |
| 2LMS | A single galnac residue on threonine-106 modifies the dynamics and the structure of interferon… | solution nmr | A | — | — |
| 3S9D | binary complex between IFNa2 and IFNAR2 | x-ray diffraction | A, C | — | — |
| 3S9D | Binary complex between IFNA2 and IFNAR2 | x-ray diffraction | A, C | — | — |
| 4YPG | Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal… | x-ray diffraction | C, D | — | — |
| 4YPG | Structural insights into the neutralization properties of a human anti-interferon monoclonal… | x-ray diffraction | C, D | — | — |
| 4Z5R | Rontalizumab Fab bound to Interferon-a2 | x-ray diffraction | D, E, F, G, H, I, X, N | — | — |
| 4Z5R | Rontalizumab Fab bound to interferon-A2 | x-ray diffraction | D, E, F, G, H, I, X, N | — | — |
| P01563 | AlphaFold monomer V2.0 prediction for interferon alpha-2 (P01563) | predicted | A | — | 2 (best 0.53) |
Experiment against prediction
- 1RH2 chain F against the predicted model P01563: TM-score 0.99, RMSD 0.50 Å
- 1RH2 chain F against the predicted model P01563: TM-score 0.99, RMSD 0.50 Å
- 1RH2 chain E against the predicted model P01563: TM-score 0.98, RMSD 0.55 Å
- 1RH2 chain E against the predicted model P01563: TM-score 0.98, RMSD 0.55 Å
- 3S9D chain A against the predicted model P01563: TM-score 0.98, RMSD 0.55 Å
- 3S9D chain A against the predicted model P01563: TM-score 0.98, RMSD 0.55 Å
- 1RH2 chain D against the predicted model P01563: TM-score 0.98, RMSD 0.59 Å
- 1RH2 chain D against the predicted model P01563: TM-score 0.98, RMSD 0.59 Å
- 1RH2 chain C against the predicted model P01563: TM-score 0.98, RMSD 0.72 Å
- 1RH2 chain C against the predicted model P01563: TM-score 0.98, RMSD 0.72 Å
Elsewhere
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