Research workbench
Crystal structure of human 4-hydroxy-2-oxoglutarate aldolase
Analyse Crystal structure of human 4-hydroxy-2-oxoglutarate aldolase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S5N
- Type
- protein
- Length
- 295 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- EC
- 4.1.3.16
- UniProt
- Q86XE5
- Ligands
- K, NA
- Pockets
- 1 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) | protein | 295 | 52% helix, 13% strand | Q86XE5 |
Ligands and binding sites
- K · Potassium ion · metal · chains A
- NA · Sodium ion · metal · chains A
- EDO · 1,2-ethanediol · additive · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 290 | 0.57 | 0.77 | 43 | EDO |
Compared structures
- 3S5N · Crystal Structure of Human 4-hydroxy-2-oxoglutarate Aldolase · the same entry in another collection · chain A against A, TM-score 1.00
- Q86XE5 · AlphaFold monomer V2.0 prediction for 4-hydroxy-2-oxoglutarate aldolase, mitochondrial… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86XE5
- Elsewhere: RCSB PDB 3S5N · PDBe 3S5N · UniProt Q86XE5
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