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Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite plasmodium falciparum
Analyse Crystal structures of falcilysin, a M16 metalloprotease from the malaria… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S5I
- Type
- protein
- Length
- 1,093 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Falcilysin
- UniProt
- Q76NL8
- Pockets
- 17 · best druggability 0.85
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Falcilysin | protein | 1093 | 48% helix, 19% strand | Q76NL8 |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1196 | 0.85 | 0.86 | 138 | empty |
| 2 | 704 | 0.70 | 0.77 | 62 | empty |
| 3 | 168 | 0.61 | 0.83 | 25 | empty |
| 4 | 354 | 0.59 | 0.76 | 30 | empty |
| 5 | 201 | 0.55 | 0.79 | 36 | empty |
Compared structures
- 3S5I · Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q76NL8
- Elsewhere: RCSB PDB 3S5I · PDBe 3S5I · UniProt Q76NL8
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