UniProt Q76NL8
Falcilysin (Q76NL8)
Falcilysin (UniProt Q76NL8), EC 3.4.24.-: 16 experimental structures on GenesisL1, 7 ligands bound, 149 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q76NL8
- Protein
- Falcilysin
- EC
- 3.4.24.-
- Experimental structures
- 16
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 149 · 8 records with a druggable one
Structures
16 records of Q76NL8 in the MolNFT archive: 16 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3S5H | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium… | x-ray diffraction | A | — | — |
| 3S5H | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite plasmodium… | x-ray diffraction | A | — | — |
| 3S5I | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium… | x-ray diffraction | A | — | — |
| 3S5I | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite plasmodium… | x-ray diffraction | A | — | — |
| 3S5K | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium… | x-ray diffraction | A | — | — |
| 3S5K | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite plasmodium… | x-ray diffraction | A | — | — |
| 3S5M | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite Plasmodium… | x-ray diffraction | A | — | — |
| 3S5M | Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite plasmodium… | x-ray diffraction | A | — | — |
| 7DI7 | Falcilysin in complex with chloroquine | x-ray diffraction | A | CLQ, ZN | 20 (best 0.80) |
| 7DIA | Falcilysin in complex with mefloquine | x-ray diffraction | A | H8O, YMZ, ZN | 16 (best 0.82) |
| 7DIJ | Falcilysin in complex with MK-4815 | x-ray diffraction | A | H8F, ZN | 19 (best 0.80) |
| 8HO4 | Falcilysin in complex with MMV000848 | x-ray diffraction | A | XUH, ZN | 20 (best 0.81) |
| 8WXW | Falcilysin in complex with hemoglobin alpha chain peptide | x-ray diffraction | A | ZN, CL | 20 (best 0.83) |
| 8WXZ | Falcilysin in complex with hemoglobin beta chain peptide | x-ray diffraction | A | ZN | 20 (best 0.75) |
| 8WYT | Partially closed Falcilysin bound to MK-4815, from MK-4815-treated dataset | electron microscopy | A | H8F, ZN | 17 (best 0.79) |
| 8WYX | Partially closed falcilysin, from free falcilysin dataset | electron microscopy | A | ZN | 17 (best 0.80) |
Ligands
- ZN · Zinc ion · in 8 records
- H8F · 2-(aminomethyl)-3,5-ditert-butyl-phenol · in 2 records
- CL · Chloride ion · in 1 record
- CLQ · N4-(7-chloro-quinolin-4-yl)-N1,N1-diethyl-pentane-1,4-diamine · in 1 record
- H8O · (S)-[2,8-bis(trifluoromethyl)quinolin-4-yl]-[(2S)-piperidin-2-yl]methanol · in 1 record
- XUH · (2R)-1-(9H-carbazol-9-yl)-3-(cyclopentylamino)propan-2-ol · in 1 record
- YMZ · (11R,12S)- Mefloquine · in 1 record
Elsewhere
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