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Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite plasmodium falciparum

Analyse Crystal structures of falcilysin, a M16 metalloprotease from the malaria… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3S5H
Type: protein
Length: 1,078 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Falcilysin
UniProt: Q76NL8
Ligands: CO
Pockets: 19 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Falcilysin	protein	1078	48% helix, 19% strand	Q76NL8

Ligands and binding sites

CO · Cobalt (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1186	0.85	0.86	147	empty
2	469	0.68	0.79	42	empty
3	187	0.61	0.83	25	empty
4	338	0.59	0.77	29	empty
5	204	0.57	0.80	43	empty

Compared structures

3S5H · Crystal structures of falcilysin, a M16 metalloprotease from the malaria parasite… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q76NL8
Elsewhere: RCSB PDB 3S5H · PDBe 3S5H · UniProt Q76NL8

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