Research workbench
Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and pH 7.5
Analyse Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and pH 7.5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S3W
- Type
- protein
- Length
- 1,194 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amiloride-sensitive cation channel 2, neuronal
- UniProt
- Q1XA76
- Ligands
- NAG, CL
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amiloride-sensitive cation channel 2, neuronal | protein | 396 | 34% helix, 26% strand | Q1XA76 |
| B | Amiloride-sensitive cation channel 2, neuronal | protein | 397 | 33% helix, 26% strand | Q1XA76 |
| C | Amiloride-sensitive cation channel 2, neuronal | protein | 401 | 36% helix, 26% strand | Q1XA76 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains A, B, C
- CL · Chloride ion · ion · 3 copies · chains A, C, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 297 | 0.83 | 0.95 | 38 | empty |
| 2 | 364 | 0.80 | 0.90 | 65 | empty |
| 3 | 233 | 0.80 | 0.93 | 39 | empty |
| 4 | 364 | 0.79 | 0.89 | 71 | empty |
| 5 | 502 | 0.78 | 0.85 | 39 | empty |
Interfaces
3 interfaces between chains.
- B–C · 2522 Ų buried · 38 hydrogen bonds · protein-protein
- A–C · 2456 Ų buried · 39 hydrogen bonds · protein-protein
- A–B · 2331 Ų buried · 40 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 21 disulfide, 6 glycan (disulfide, N-glycosylation).
Compared structures
- 3S3W · Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and ph 7.5 · the same entry in another collection · chain A against A, TM-score 1.00
- Q1XA76 · AlphaFold monomer V2.0 prediction for acid-sensing ion channel 1 (Q1XA76) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1XA76
- Elsewhere: RCSB PDB 3S3W · PDBe 3S3W · UniProt Q1XA76
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