UniProt Q1XA76
Acid-sensing ion channel 1 (Q1XA76)
Acid-sensing ion channel 1 (UniProt Q1XA76): 40 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 97 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q1XA76
- Protein
- Acid-sensing ion channel 1
- Experimental structures
- 40
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 97 · 7 records with a druggable one
Structures
41 records of Q1XA76 in the MolNFT archive: 40 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2QTS | Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH | x-ray diffraction | A, B, C, D, E, F | — | — |
| 2QTS | Structure of an acid-sensing ion channel 1 at 1.9 a resolution and low pH | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3IJ4 | Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized… | x-ray diffraction | A | — | — |
| 3IJ4 | Cesium sites in the crystal structure of a functional acid sensing ion channel in the desensitized… | x-ray diffraction | A | — | — |
| 3S3W | Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and ph 7.5 | x-ray diffraction | A, B, C | — | — |
| 3S3W | Structure of chicken acid-sensing ion channel 1 at 2.6 a resolution and pH 7.5 | x-ray diffraction | A, B, C | — | — |
| 3S3X | Structure of chicken acid-sensing ion channel 1 AT 3.0 A resolution in complex with psalmotoxin | x-ray diffraction | A, B, C | — | — |
| 3S3X | Structure of chicken acid-sensing ion channel 1 at 3.0 a resolution in complex with psalmotoxin | x-ray diffraction | A, B, C | — | — |
| 4FZ0 | Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at low pH | x-ray diffraction | A, B, C | — | — |
| 4FZ0 | Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at low pH | x-ray diffraction | A, B, C | — | — |
| 4FZ1 | Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH | x-ray diffraction | A | — | — |
| 4FZ1 | Crystal structure of acid-sensing ion channel in complex with psalmotoxin 1 at high pH | x-ray diffraction | A | — | — |
| 4NTW | Structure of acid-sensing ion channel in complex with snake toxin | x-ray diffraction | A | — | — |
| 4NTW | Structure of acid-sensing ion channel in complex with snake toxin | x-ray diffraction | A | — | — |
| 4NTX | Structure of acid-sensing ion channel in complex with snake toxin and amiloride | x-ray diffraction | A | — | — |
| 4NTX | Structure of acid-sensing ion channel in complex with snake toxin and amiloride | x-ray diffraction | A | — | — |
| 4NTY | Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin | x-ray diffraction | A | — | — |
| 4NTY | Cesium sites in the crystal structure of acid-sensing ion channel in complex with snake toxin | x-ray diffraction | A | — | — |
| 4NYK | Structure of a membrane protein | x-ray diffraction | A | — | — |
| 4NYK | Structure of a membrane protein | x-ray diffraction | A | — | — |
| 5WKU | Structure of an acid sensing ion channel in a resting state with barium | x-ray diffraction | A, C, B | NAG, CL, BA | 15 (best 0.81) |
| 5WKU | Structure of an acid sensing ion channel in a resting state with barium | x-ray diffraction | A, C, B | NAG, CL, BA | — |
| 5WKV | Structure of an acid sensing ion channel in a resting state with calcium | x-ray diffraction | A, C, B | NAG, CL, CA | 16 (best 0.80) |
| 5WKV | Structure of an acid sensing ion channel in a resting state with calcium | x-ray diffraction | A, C, B | NAG, CL, CA | — |
| 5WKX | Barium sites in the structure of a resting acid sensing ion channel | x-ray diffraction | A, C, B | NAG, CL, BA | 18 (best 0.78) |
| 5WKX | Barium sites in the structure of a resting acid sensing ion channel | x-ray diffraction | A, C, B | NAG, CL, BA | — |
| 5WKY | Bromide sites in the structure of an acid sensing ion channel in a resting state | x-ray diffraction | A, C, B | NAG, CL, BA | 18 (best 0.78) |
| 5WKY | Bromide sites in the structure of an acid sensing ion channel in a resting state | x-ray diffraction | A, C, B | NAG, CL, BA | — |
| 6AVE | Structure of an acid sensing ion channel in a resting state at high pH | electron microscopy | A, B, C | NAG | 14 (best 0.81) |
| 6AVE | Structure of an acid sensing ion channel in a resting state at high pH | electron microscopy | A, B, C | NAG | — |
| 6CMC | Barium sites in the structure of a desensitized acid sensing ion channel | x-ray diffraction | A | CL | 3 (best 0.63) |
| 6CMC | Barium sites in the structure of a desensitized acid sensing ion channel | x-ray diffraction | A | CL | — |
| 6VTK | Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized… | electron microscopy | A, C, B | NAG | — |
| 6VTK | Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized… | electron microscopy | A, C, B | NAG | — |
| 6VTL | Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a resting state… | electron microscopy | A, C, B | NAG | — |
| 6VTL | Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a resting state… | electron microscopy | A, C, B | NAG | — |
| 6X9H | Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1… | x-ray diffraction | A, B, C | NAG, UZG, NA | 13 (best 0.89) |
| 6X9H | Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1… | x-ray diffraction | A, B, C | NAG, UZG, NA | — |
| 7LIE | The isolated chicken ASIC1a thumb domain (ATD-c1a) retains the structure and ligand binding… | solution nmr | A | — | — |
| 7LIE | The isolated chicken ASIC1A thumb domain (atd-C1A) retains the structure and ligand binding… | solution nmr | A | — | — |
| Q1XA76 | AlphaFold monomer V2.0 prediction for acid-sensing ion channel 1 (Q1XA76) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6X9H chain B against the predicted model Q1XA76: TM-score 0.98, RMSD 1.16 Å
- 6X9H chain B against the predicted model Q1XA76: TM-score 0.98, RMSD 1.16 Å
- 6X9H chain A against the predicted model Q1XA76: TM-score 0.97, RMSD 1.24 Å
- 6X9H chain A against the predicted model Q1XA76: TM-score 0.97, RMSD 1.24 Å
- 6X9H chain C against the predicted model Q1XA76: TM-score 0.97, RMSD 1.32 Å
- 6X9H chain C against the predicted model Q1XA76: TM-score 0.97, RMSD 1.32 Å
- 5WKU chain A against the predicted model Q1XA76: TM-score 0.97, RMSD 1.46 Å
- 5WKU chain A against the predicted model Q1XA76: TM-score 0.97, RMSD 1.46 Å
- 5WKY chain A against the predicted model Q1XA76: TM-score 0.97, RMSD 1.46 Å
- 5WKY chain A against the predicted model Q1XA76: TM-score 0.97, RMSD 1.46 Å
Elsewhere
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