MolNFT v1 · #169359 · protein
Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)
6X9H: “Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion channel 1 (ASIC1)”. X-ray diffraction, 3 ligands (UZG, NAG, NA). MolNFT v1 #169359 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6X9H
- Type
- protein
- Length
- 1,222 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q1XA76
- Ligands
- UZG, NAG, NA
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 409 | — | Q1XA76 |
| B | — | protein | 410 | — | Q1XA76 |
| C | — | protein | 403 | — | Q1XA76 |
Ligands and binding sites
- UZG · 2-[4-(3,4-dimethoxyphenoxy)phenyl]-1H-benzimidazole-6-carboximidamide · ligand · 3 copies · chains A, B, C
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A, B, C
- NA · Sodium ion · metal · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6X9H · Molecular mechanism and structural basis of small-molecule modulation of acid-sensing ion… · the same entry in another collection · chain A against A, TM-score 1.00
- Q1XA76 · AlphaFold monomer V2.0 prediction for acid-sensing ion channel 1 (Q1XA76) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q1XA76
- Elsewhere: RCSB PDB 6X9H · PDBe 6X9H · UniProt Q1XA76
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