Research workbench
GLU381SER mutant of maize cytokinin OXIDASE/DEHYDROGENASE complexed with N6-isopentenyladenosine
Analyse GLU381SER mutant of maize cytokinin OXIDASE/DEHYDROGENASE complexed with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3S1D
- Type
- protein
- Length
- 498 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytokinin dehydrogenase 1
- EC
- 1.5.99.12
- UniProt
- Q9T0N8
- Ligands
- FAD, ZIR, NAG
- Pockets
- 5 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cytokinin dehydrogenase 1 (EC 1.5.99.12) | protein | 498 | 37% helix, 22% strand | Q9T0N8 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
- ZIR · N-(3-methylbut-2-en-1-yl)adenosine · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
- GOL · Glycerol · additive · 5 copies · chains A
- PEG · Di(hydroxyethyl)ether · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 802 | 0.86 | 0.88 | 82 | FAD, ZIR |
| 2 | 313 | 0.61 | 0.79 | 30 | GOL |
| 3 | 56 | 0.34 | 0.77 | 15 | GOL |
| 4 | 85 | 0.33 | 0.75 | 15 | empty |
| 5 | 59 | 0.32 | 0.77 | 20 | empty |
Modifications
Observed in the structure: 3 glycan, 1 cofactor (N-glycosylation, flavinylation).
Compared structures
- 3S1D · Glu381Ser mutant of maize cytokinin oxidase/dehydrogenase complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9T0N8 · AlphaFold monomer V2.0 prediction for cytokinin dehydrogenase 1 (Q9T0N8) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9T0N8
- Elsewhere: RCSB PDB 3S1D · PDBe 3S1D · UniProt Q9T0N8
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