Research workbench
Crystal structure of LGN/MINSCUTEABLE complex
Analyse Crystal structure of LGN/MINSCUTEABLE complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RO3
- Type
- protein
- Length
- 176 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein-signaling modulator 2; Peptide of protein inscuteable homolog
- UniProt
- Q8VDU0, Q3HNM7
- Ligands
- CL
- Pockets
- 1 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-protein-signaling modulator 2 | protein | 159 | 86% helix, 0% strand | Q8VDU0 |
| B | Peptide of protein inscuteable homolog | protein | 17 | 59% helix, 0% strand | Q3HNM7 |
Ligands and binding sites
- CL · Chloride ion · ion · 5 copies · chains A
- GOL · Glycerol · additive · chains A
- EOH · Ethanol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.48 | 0.77 | 25 | CL |
Interfaces
1 interface between chains.
- A–B · 889 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 3RO3 · crystal structure of LGN/mInscuteable complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VDU0 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (Q8VDU0) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q3HNM7 · AlphaFold monomer V2.0 prediction for protein inscuteable homolog (Q3HNM7) · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VDU0
- Every structure of UniProt Q3HNM7
- Elsewhere: RCSB PDB 3RO3 · PDBe 3RO3 · UniProt Q8VDU0 · UniProt Q3HNM7
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