Research workbench
Structures of the LGN/NUMA complex
Analyse Structures of the LGN/NUMA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RO2
- Type
- protein
- Length
- 350 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- G-protein-signaling modulator 2; Peptide of nuclear mitotic apparatus protein 1
- UniProt
- Q8VDU0, Q14980
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | G-protein-signaling modulator 2 | protein | 328 | 85% helix, 0% strand | Q8VDU0 |
| B | Peptide of nuclear mitotic apparatus protein 1 | protein | 22 | 14% helix, 0% strand | Q14980 |
Ligands and binding sites
- GOL · Glycerol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 322 | 0.70 | 0.84 | 50 | GOL |
| 2 | 82 | 0.46 | 0.81 | 20 | empty |
| 3 | 165 | 0.46 | 0.76 | 24 | GOL |
Interfaces
1 interface between chains.
- A–B · 1601 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 3RO2 · Structures of the LGN/NuMA complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8VDU0 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (Q8VDU0) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q14980 · AlphaFold monomer V2.0 prediction for nuclear mitotic apparatus protein 1 (Q14980) · a predicted model of the same protein · chain B against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8VDU0
- Every structure of UniProt Q14980
- Elsewhere: RCSB PDB 3RO2 · PDBe 3RO2 · UniProt Q8VDU0 · UniProt Q14980
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