Research workbench
Three-dimensional structure of a transglutaminase: human blood coagulation factor xiii
Analyse Three-dimensional structure of a transglutaminase: human blood coagulation… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1GGT
- Type
- protein
- Length
- 1,418 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Coagulation factor xiii
- EC
- 2.3.2.13
- UniProt
- P00488
- Pockets
- 20 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Coagulation factor xiii (EC 2.3.2.13) | protein | 710 | 15% helix, 41% strand | P00488 |
| B | Coagulation factor xiii (EC 2.3.2.13) | protein | 708 | 14% helix, 41% strand | P00488 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 640 | 0.67 | 0.76 | 67 | empty |
| 2 | 109 | 0.62 | 0.87 | 24 | empty |
| 3 | 97 | 0.60 | 0.87 | 23 | empty |
| 4 | 115 | 0.60 | 0.86 | 25 | empty |
| 5 | 209 | 0.53 | 0.77 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 958 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 1GGT · Three-dimensional structure of a transglutaminase: human blood coagulation factor xiii · the same entry in another collection · chain A against A, TM-score 1.00
- P00488 · AlphaFold monomer V2.0 prediction for coagulation factor xiii a chain (P00488) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00488
- Elsewhere: RCSB PDB 1GGT · PDBe 1GGT · UniProt P00488
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