Research workbench
ETS1 cooperative binding to widely separated sites on promoter DNA
Analyse ETS1 cooperative binding to widely separated sites on promoter DNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RI4
- Type
- protein + DNA
- Length
- 336 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein C-ets-1; TCR alpha promoter DNA
- UniProt
- P14921
- Pockets
- 4 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 49% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Protein C-ets-1 | protein | 136 | 49% helix, 9% strand | P14921 |
| B, E | TCR alpha promoter DNA | dna | 16 | — | — |
| C, F | TCR alpha promoter DNA | dna | 16 | — | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1170 | 0.76 | 0.78 | 94 | empty |
| 2 | 60 | 0.38 | 0.80 | 17 | empty |
| 3 | 125 | 0.36 | 0.73 | 15 | empty |
| 4 | 52 | 0.29 | 0.75 | 15 | empty |
Interfaces
12 interfaces between chains.
- A–D · 655 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 651 Ų buried · 58 hydrogen bonds · nucleic-nucleic
- E–F · 649 Ų buried · 57 hydrogen bonds · nucleic-nucleic
- D–F · 553 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–C · 544 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14921
- Elsewhere: RCSB PDB 3RI4 · PDBe 3RI4 · UniProt P14921
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