Research workbench
Structure and functional analysis of a new subfamily of glycosyltransferases required for glycosylation of serine-rich streptococcal adhesions
Analyse Structure and functional analysis of a new subfamily of glycosyltransferases… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RHZ
- Type
- protein
- Length
- 656 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nucleotide sugar synthetase-like protein
- UniProt
- B5A7L9
- Ligands
- UDP, CL
- Pockets
- 10 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nucleotide sugar synthetase-like protein | protein | 330 | 44% helix, 19% strand | B5A7L9 |
| B | Nucleotide sugar synthetase-like protein | protein | 326 | 43% helix, 17% strand | B5A7L9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 388 | 0.74 | 0.84 | 43 | UDP |
| 2 | 395 | 0.72 | 0.83 | 44 | UDP, CL |
| 3 | 122 | 0.42 | 0.76 | 20 | empty |
| 4 | 109 | 0.40 | 0.76 | 20 | empty |
| 5 | 96 | 0.39 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1075 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3RHZ · Structure and functional analysis of a new subfamily of glycosyltransferases required for… · the same entry in another collection · chain A against A, TM-score 1.00
- B5A7L9 · AlphaFold monomer V2.0 prediction for glucosyltransferase 3 (B5A7L9) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B5A7L9
- Elsewhere: RCSB PDB 3RHZ · PDBe 3RHZ · UniProt B5A7L9
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