Research workbench
Crystal structure of C-terminal truncation of udp-glucose pyrophosphorylase of homo sapiens
Analyse Crystal structure of C-terminal truncation of udp-glucose pyrophosphorylase of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3R3I
- Type
- protein
- Length
- 1,819 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UTP--glucose-1-phosphate uridylyltransferase
- EC
- 2.7.7.9
- UniProt
- Q16851
- Pockets
- 20 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 25% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 457 | 22% helix, 25% strand | Q16851 |
| B | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 463 | 28% helix, 25% strand | Q16851 |
| C | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 439 | 20% helix, 21% strand | Q16851 |
| D | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 460 | 30% helix, 24% strand | Q16851 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 536 | 0.74 | 0.82 | 60 | empty |
| 2 | 726 | 0.74 | 0.79 | 75 | empty |
| 3 | 423 | 0.68 | 0.80 | 51 | empty |
| 4 | 63 | 0.65 | 0.93 | 15 | empty |
| 5 | 306 | 0.64 | 0.80 | 27 | empty |
Interfaces
4 interfaces between chains.
- A–C · 898 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 247 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 239 Ų buried · 3 hydrogen bonds · protein-protein
- A–D · 15 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3R3I · Crystal Structure of C-terminal truncation of UDP-glucose Pyrophosphorylase of Homo… · the same entry in another collection · chain D against D, TM-score 1.00
- Q16851 · AlphaFold monomer V2.0 prediction for UTP--glucose-1-phosphate uridylyltransferase… · a predicted model of the same protein · chain D against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16851
- Elsewhere: RCSB PDB 3R3I · PDBe 3R3I · UniProt Q16851
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.