Research workbench
Crystal structure of udp-glucose pyrophosphorylase of homo sapiens
Analyse Crystal structure of udp-glucose pyrophosphorylase of homo sapiens in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3R2W
- Type
- protein
- Length
- 1,850 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- UTP--glucose-1-phosphate uridylyltransferase
- EC
- 2.7.7.9
- UniProt
- Q16851
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 24% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 465 | 23% helix, 27% strand | Q16851 |
| B | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 467 | 27% helix, 28% strand | Q16851 |
| C | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 450 | 18% helix, 22% strand | Q16851 |
| D | UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) | protein | 468 | 26% helix, 27% strand | Q16851 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1085 | 0.76 | 0.79 | 132 | empty |
| 2 | 689 | 0.69 | 0.76 | 76 | empty |
| 3 | 287 | 0.61 | 0.79 | 29 | empty |
| 4 | 455 | 0.60 | 0.75 | 46 | empty |
| 5 | 54 | 0.60 | 0.91 | 24 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1017 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 891 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 878 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 170 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 150 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 3R2W · Crystal Structure of UDP-glucose Pyrophosphorylase of Homo Sapiens · the same entry in another collection · chain D against D, TM-score 1.00
- Q16851 · AlphaFold monomer V2.0 prediction for UTP--glucose-1-phosphate uridylyltransferase… · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16851
- Elsewhere: RCSB PDB 3R2W · PDBe 3R2W · UniProt Q16851
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