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Crystal structure of titin domain M4, tetragonal form

Analyse Crystal structure of titin domain M4, tetragonal form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3QP3
Type: protein
Length: 298 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Titin
EC: 2.7.11.1
UniProt: Q8WZ42
Ligands: SO4
Pockets: 1 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 3% helix, 62% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Titin (EC 2.7.11.1)	protein	101	3% helix, 61% strand	Q8WZ42
B	Titin (EC 2.7.11.1)	protein	100	3% helix, 62% strand	Q8WZ42
C	Titin (EC 2.7.11.1)	protein	97	3% helix, 64% strand	Q8WZ42

Ligands and binding sites

SO4 · Sulfate ion · ion · 7 copies · chains A, C, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	850	0.71	0.76	69	empty

Interfaces

3 interfaces between chains.

B–C · 448 Å² buried · 9 hydrogen bonds · protein-protein
A–C · 371 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 63 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3QP3 · Crystal structure of titin domain M4, tetragonal form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WZ42
Elsewhere: RCSB PDB 3QP3 · PDBe 3QP3 · UniProt Q8WZ42

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