Research workbench
Crystal structure of the GLUK2/GLUK5 (GLUR6/KA2) atd tetramer assembly
Analyse Crystal structure of the GLUK2/GLUK5 (GLUR6/KA2) atd tetramer assembly in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3QLV
- Type
- protein
- Length
- 3,760 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor, ionotropic kainate 5; Glutamate receptor, ionotropic kainate 2
- UniProt
- Q63273, P42260
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, E, G, I | Glutamate receptor, ionotropic kainate 5 | protein | 371 | 33% helix, 18% strand | Q63273 |
| C, D, F, H, J | Glutamate receptor, ionotropic kainate 2 | protein | 381 | 33% helix, 17% strand | P42260 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 978 | 0.81 | 0.82 | 106 | empty |
| 2 | 1178 | 0.80 | 0.81 | 120 | empty |
| 3 | 1171 | 0.80 | 0.81 | 112 | empty |
| 4 | 1145 | 0.80 | 0.81 | 109 | empty |
| 5 | 579 | 0.75 | 0.82 | 68 | empty |
Interfaces
9 interfaces between chains.
- E–F · 1707 Ų buried · 23 hydrogen bonds · protein-protein
- G–H · 1665 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 1662 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 1616 Ų buried · 17 hydrogen bonds · protein-protein
- I–J · 1560 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 20 disulfide (disulfide).
Compared structures
- 3QLV · Crystal structure of the GluK2/GluK5 (GluR6/KA2) ATD tetramer assembly · the same entry in another collection · chain J against J, TM-score 1.00
- Q63273 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, kainate 5 (Q63273) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q63273
- Every structure of UniProt P42260
- Elsewhere: RCSB PDB 3QLV · PDBe 3QLV · UniProt Q63273 · UniProt P42260
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