Research workbench
Structure of CRISPR-associated protein CSN2
Analyse Structure of CRISPR-associated protein CSN2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3QHQ
- Type
- protein
- Length
- 433 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SAG0897 family CRISPR-associated protein
- EC
- 2.7.7.6
- UniProt
- E7S4M0
- Ligands
- CA
- Pockets
- 4 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SAG0897 family CRISPR-associated protein (EC 2.7.7.6) | protein | 222 | 43% helix, 17% strand | E7S4M0 |
| B | SAG0897 family CRISPR-associated protein (EC 2.7.7.6) | protein | 211 | 45% helix, 13% strand | E7S4M0 |
Ligands and binding sites
- CA · Calcium ion · metal · 5 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.58 | 0.79 | 27 | empty |
| 2 | 53 | 0.48 | 0.86 | 15 | empty |
| 3 | 73 | 0.36 | 0.77 | 16 | empty |
| 4 | 70 | 0.31 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1074 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E7S4M0
- Elsewhere: RCSB PDB 3QHQ · PDBe 3QHQ · UniProt E7S4M0
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