Research workbench
Crystal structure of human pacsin 2 F-bar
Analyse Crystal structure of human pacsin 2 F-bar in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3Q0K
- Type
- protein
- Length
- 1,150 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein kinase C and casein kinase substrate in neurons protein 2
- UniProt
- Q9UNF0
- Ligands
- CA
- Pockets
- 10 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 81% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein kinase C and casein kinase substrate in neurons protein 2 | protein | 287 | 81% helix, 1% strand | Q9UNF0 |
| B | Protein kinase C and casein kinase substrate in neurons protein 2 | protein | 287 | 82% helix, 1% strand | Q9UNF0 |
| C | Protein kinase C and casein kinase substrate in neurons protein 2 | protein | 287 | 83% helix, 1% strand | Q9UNF0 |
| D | Protein kinase C and casein kinase substrate in neurons protein 2 | protein | 289 | 80% helix, 1% strand | Q9UNF0 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 865 | 0.69 | 0.75 | 64 | empty |
| 2 | 381 | 0.63 | 0.78 | 33 | empty |
| 3 | 67 | 0.60 | 0.90 | 17 | empty |
| 4 | 66 | 0.59 | 0.90 | 19 | empty |
| 5 | 144 | 0.56 | 0.82 | 19 | empty |
Interfaces
3 interfaces between chains.
- C–D · 4555 Ų buried · 36 hydrogen bonds · protein-protein
- A–B · 4418 Ų buried · 41 hydrogen bonds · protein-protein
- A–C · 525 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNF0
- Elsewhere: RCSB PDB 3Q0K · PDBe 3Q0K · UniProt Q9UNF0
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