Research workbench
Crystal structure of SUVH5 sra- methylated chh DNA complex
Analyse Crystal structure of SUVH5 sra- methylated chh DNA complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3Q0F
- Type
- protein + DNA
- Length
- 312 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5; DNA…
- EC
- 2.1.1.43
- UniProt
- O82175
- Pockets
- 5 · best druggability 0.66
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (EC 2.1.1.43) | protein | 145 | 12% helix, 36% strand | O82175 |
| A | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (EC 2.1.1.43) | protein | 146 | 12% helix, 36% strand | O82175 |
| B | DNA (5'-D(*CP*TP*GP*AP*GP*GP*AP*GP*TP*AP*T)-3') | dna | 11 | — | — |
| C | DNA (5'-D(*TP*AP*CP*TP*(5CM)P*CP*TP*CP*AP*G)-3') | dna | 10 | — | — |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 236 | 0.66 | 0.84 | 30 | empty |
| 2 | 208 | 0.65 | 0.84 | 22 | empty |
| 3 | 89 | 0.29 | 0.72 | 14 | empty |
| 4 | 68 | 0.28 | 0.73 | 12 | empty |
| 5 | 60 | 0.26 | 0.73 | 12 | empty |
Interfaces
6 interfaces between chains.
- A–B · 601 Ų buried · 17 hydrogen bonds · protein-nucleic
- X–C · 567 Ų buried · 15 hydrogen bonds · protein-nucleic
- B–C · 420 Ų buried · 38 hydrogen bonds · nucleic-nucleic
- X–A · 274 Ų buried · 0 hydrogen bonds · protein-protein
- X–B · 244 Ų buried · 3 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 1 modified (nucleotide modification).
Compared structures
- 3Q0F · Crystal structure of SUVH5 SRA- methylated CHH DNA complex · the same entry in another collection · chain X against X, TM-score 1.00
- O82175 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-9… · a predicted model of the same protein · chain X against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O82175
- Elsewhere: RCSB PDB 3Q0F · PDBe 3Q0F · UniProt O82175
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