MolNFT v1 · #442411 · protein
AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (O82175)
O82175: “AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 (O82175)”. 12 pockets (best druggability 0.77). MolNFT v1 #442411 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O82175
- Type
- protein
- Length
- 794 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x2A70886e2AB13F20e22Df99DEc0896F1AC056Af4
- Molecule
- Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5
- UniProt
- O82175
- Pockets
- 12 · best druggability 0.77
Structure
1 distinct chain · 13% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5 | protein | 794 | 13% helix, 18% strand | O82175 |
Pockets
12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 637 | 0.77 | 0.83 | 65 | empty |
| 2 | 1054 | 0.75 | 0.78 | 89 | empty |
| 3 | 58 | 0.68 | 0.96 | 18 | empty |
| 4 | 108 | 0.61 | 0.87 | 20 | empty |
| 5 | 368 | 0.56 | 0.75 | 43 | empty |
Compared structures
- 4YGI · Crystal Structure of SUVH5 SRA bound to fully hydroxymethylated CG DNA · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 4YGI · Crystal structure of SUVH5 sra bound to fully hydroxymethylated cg DNA · an experimental structure of the same protein · chain A against A, TM-score 0.19
- 3Q0B · Crystal structure of SUVH5 sra- fully methylated cg DNA complex in space group P42212 · an experimental structure of the same protein · chain A against X, TM-score 0.18
- 3Q0B · Crystal structure of SUVH5 SRA- fully methylated CG DNA complex in space group P42212 · an experimental structure of the same protein · chain A against X, TM-score 0.18
- 3Q0C · Crystal structure of SUVH5 SRA-fully methylated CG DNA complex in space group P6122 · an experimental structure of the same protein · chain A against X, TM-score 0.18
- 3Q0C · Crystal structure of SUVH5 sra-fully methylated cg DNA complex in space group P6122 · an experimental structure of the same protein · chain A against X, TM-score 0.18
- 3Q0F · Crystal structure of SUVH5 SRA- methylated CHH DNA complex · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 3Q0F · Crystal structure of SUVH5 sra- methylated chh DNA complex · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 3Q0D · Crystal structure of SUVH5 sra- hemi methylated cg DNA complex · an experimental structure of the same protein · chain A against A, TM-score 0.18
- 3Q0D · Crystal structure of SUVH5 SRA- hemi methylated CG DNA complex · an experimental structure of the same protein · chain A against A, TM-score 0.18
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O82175
- Elsewhere: UniProt O82175 · AlphaFold DB O82175
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