Research workbench
Reduced sweetness of a monellin (mnei) mutant results from increased protein flexibility and disruption of a distant poly-(L-proline) II helix
Analyse Reduced sweetness of a monellin (mnei) mutant results from increased protein… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3PXM
- Type
- protein
- Length
- 192 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monellin chain B/MONELLIN chain a chimeric protein
- UniProt
- P02882, P02881
- Pockets
- 1 · best druggability 0.50
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Monellin chain B/MONELLIN chain a chimeric protein | protein | 96 | 18% helix, 50% strand | P02882, P02881 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 198 | 0.50 | 0.77 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 585 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 3PXM · Reduced sweetness of a monellin (MNEI) mutant results from increased protein flexibility… · the same entry in another collection · chain A against A, TM-score 1.00
- P02882 · AlphaFold monomer V2.0 prediction for monellin chain B (P02882) · a predicted model of the same protein · chain A against A, TM-score 0.48
- P02881 · AlphaFold monomer V2.0 prediction for monellin chain a (P02881) · a predicted model of the same protein · chain A against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02882
- Every structure of UniProt P02881
- Elsewhere: RCSB PDB 3PXM · PDBe 3PXM · UniProt P02882 · UniProt P02881
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