Research workbench
Structure of MECA121 and CLPC1-485 complex
Analyse Structure of MECA121 and CLPC1-485 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3PXG
- Type
- protein
- Length
- 3,195 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adapter protein meca 1; Negative regulator of genetic competence CLPC/MECB
- UniProt
- P37958, P37571
- Pockets
- 20 · best druggability 0.81
Structure
x-ray diffraction · 7 distinct chains · 53% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| a, b, c, f | Adapter protein meca 1 | protein | 94 | 39% helix, 30% strand | P37958 |
| A | Negative regulator of genetic competence CLPC/MECB | protein | 442 | 54% helix, 6% strand | P37571 |
| B | Negative regulator of genetic competence CLPC/MECB | protein | 437 | 52% helix, 6% strand | P37571 |
| C | Negative regulator of genetic competence CLPC/MECB | protein | 444 | 54% helix, 6% strand | P37571 |
| d, e | Adapter protein meca 1 | protein | 95 | 39% helix, 29% strand | P37958 |
| D, E | Negative regulator of genetic competence CLPC/MECB | protein | 434 | 55% helix, 6% strand | P37571 |
| F | Negative regulator of genetic competence CLPC/MECB | protein | 438 | 55% helix, 6% strand | P37571 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1058 | 0.81 | 0.82 | 91 | empty |
| 2 | 99 | 0.77 | 0.98 | 25 | empty |
| 3 | 101 | 0.77 | 0.97 | 29 | empty |
| 4 | 719 | 0.77 | 0.82 | 76 | empty |
| 5 | 95 | 0.76 | 0.97 | 25 | empty |
Interfaces
18 interfaces between chains.
- b–B · 1389 Ų buried · 23 hydrogen bonds · protein-protein
- f–F · 1345 Ų buried · 23 hydrogen bonds · protein-protein
- d–D · 1323 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 1316 Ų buried · 16 hydrogen bonds · protein-protein
- c–C · 1315 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 3PXG · Structure of MecA121 and ClpC1-485 complex · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37958
- Every structure of UniProt P37571
- Elsewhere: RCSB PDB 3PXG · PDBe 3PXG · UniProt P37958 · UniProt P37571
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