Research workbench
Crystal structure analysis of pscp (pseudomonas serine-carboxyl proteinase) complexed with a fragment of tyrostatin (this enzyme renamed "sedolisin" in 2003)
Analyse Crystal structure analysis of pscp (pseudomonas serine-carboxyl proteinase)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1GA6
- Type
- protein
- Length
- 371 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serine-carboxyl proteinase; Fragment of tyrostatin
- EC
- 3.4.23.37
- UniProt
- P42790
- Ligands
- CA
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serine-carboxyl proteinase (EC 3.4.23.37) | protein | 369 | 33% helix, 27% strand | P42790 |
| I | Fragment of tyrostatin | protein | 2 | 0% helix, 0% strand | — |
Ligands and binding sites
- CA · Calcium ion · metal · chains A
- ACT · Acetate ion · additive · 4 copies · chains A
- GOL · Glycerol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.52 | 0.75 | 37 | ACT |
Interfaces
1 interface between chains.
- A–I · 210 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1GA6 · Crystal structure analysis of pscp (pseudomonas serine-carboxyl proteinase) complexed… · the same entry in another collection · chain A against A, TM-score 1.00
- P42790 · AlphaFold monomer V2.0 prediction for pseudomonalisin (P42790) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42790
- Elsewhere: RCSB PDB 1GA6 · PDBe 1GA6 · UniProt P42790
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