Research workbench
The crystal structure of gilr, an oxidoreductase that catalyzes the terminal step of gilvocarcin biosynthesis
Analyse The crystal structure of gilr, an oxidoreductase that catalyzes the terminal… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3POP
- Type
- protein
- Length
- 1,972 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gilr oxidase
- UniProt
- Q7X2G7
- Ligands
- FAD
- Pockets
- 20 · best druggability 0.87
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Gilr oxidase | protein | 493 | 33% helix, 23% strand | Q7X2G7 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 794 | 0.87 | 0.90 | 118 | FAD |
| 2 | 607 | 0.87 | 0.92 | 91 | FAD |
| 3 | 629 | 0.87 | 0.91 | 89 | FAD |
| 4 | 651 | 0.86 | 0.91 | 89 | FAD |
| 5 | 779 | 0.85 | 0.88 | 86 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1746 Ų buried · 34 hydrogen bonds · protein-protein
- A–D · 1731 Ų buried · 34 hydrogen bonds · protein-protein
- B–D · 355 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 8 cofactor (flavinylation).
Compared structures
- 3POP · The crystal structure of GilR, an oxidoreductase that catalyzes the terminal step of… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7X2G7
- Elsewhere: RCSB PDB 3POP · PDBe 3POP · UniProt Q7X2G7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.