Research workbench
Crystal structure of BCL-xl in complex with the BAXBH3 domain
Analyse Crystal structure of BCL-xl in complex with the BAXBH3 domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3PL7
- Type
- protein
- Length
- 308 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BCL-2-like protein 1; Apoptosis regulator bax
- UniProt
- Q07817, Q07812
- Pockets
- 5 · best druggability 0.49
Structure
x-ray diffraction · 3 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BCL-2-like protein 1 | protein | 141 | 77% helix, 0% strand | Q07817 |
| C | Apoptosis regulator bax | protein | 26 | 92% helix, 0% strand | Q07812 |
| B | BCL-2-like protein 1 | protein | 141 | 79% helix, 0% strand | Q07817 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 154 | 0.49 | 0.78 | 31 | empty |
| 2 | 91 | 0.42 | 0.79 | 15 | empty |
| 3 | 88 | 0.41 | 0.78 | 19 | empty |
| 4 | 86 | 0.36 | 0.76 | 15 | empty |
| 5 | 64 | 0.33 | 0.77 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1025 Ų buried · 7 hydrogen bonds · protein-protein
- C–B · 861 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 272 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 3PL7 · Crystal structure of Bcl-xL in complex with the BaxBH3 domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q07817 · AlphaFold monomer V2.0 prediction for BCL-2-like protein 1 (Q07817) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q07812 · AlphaFold monomer V2.0 prediction for apoptosis regulator bax (Q07812) · a predicted model of the same protein · chain C against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07817
- Every structure of UniProt Q07812
- Elsewhere: RCSB PDB 3PL7 · PDBe 3PL7 · UniProt Q07817 · UniProt Q07812
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