Research workbench
Crystal structure analysis of polyporus squamosus lectin bound to human-type influenza-binding epitope NEU5ACA2-6GALB1-4GLCNAC
Analyse Crystal structure analysis of polyporus squamosus lectin bound to human-type… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3PHZ
- Type
- protein
- Length
- 556 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ricin B-related lectin
- UniProt
- Q75WT9
- Ligands
- NAG, GAL, SIA
- Pockets
- 1 · best druggability 0.37
Structure
x-ray diffraction · 1 distinct chain · 20% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ricin B-related lectin | protein | 278 | 20% helix, 40% strand | Q75WT9 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
- GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
- SIA · N-acetyl-alpha-neuraminic acid · sugar · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.37 | 0.78 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1751 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 3PHZ · Crystal Structure Analysis of Polyporus squamosus lectin bound to human-type… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q75WT9
- Elsewhere: RCSB PDB 3PHZ · PDBe 3PHZ · UniProt Q75WT9
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